• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    Method for the prevention of sudden death of the infant and mattress for the infant. A method for the prevention of sudden infant death is described. The method includes the monitoring of the frequency of breathing of the infant, the detection of apneas and the application of a vibration of variable frequency when the apneas that do not awaken the infant are produced. A suitable mattress is described for the prevention of sudden death of the infant and mattress. The mattress comprises in its interior means to generate a vibration, means to control the duration of the vibration and the vibration has a variable frequency. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2630368A1
    申请号:ES201630181
    申请日:2016-02-17
    公开日:2017-08-21
    发明作者:Tomás ZAMORA ÁLVAREZ；Vicente BARBERÁ ROIG；Gonzalo PIN ARBOLEDAS；Maria MORELL SAFORT；Jaime GISBERT；Marta VALERO MARTÍNEZ；Virgine CANART；David MATTHEW SMART
    申请人:Colchones Delax S L；Colchones Delax SL；
    IPC主号:
    专利说明:

    DESCRIPTION
    Method for the prevention of sudden infant death and infant mattress
    5 Technical field of the invention
    The present invention describes a method for the prevention of sudden infant death. The method comprises the monitoring of the infant's breathing rate, the detection of apnea and the application of a variable frequency vibration when apnea occurs.
    The present invention describes a mattress suitable for the prevention of sudden death of the infant and mattress. The mattress inside comprises means for generating a vibration, means for controlling the duration of the vibration and the vibration has a variable frequency.
    A method and mattress for induction of the respiratory reflex in 15 infants with apneas are described as a mechanism to prevent sudden infant death.
    Background of the invention
    Sudden infant death is a pathology that causes the sudden and unexpected death of a child younger than a seemingly healthy anus 20 when he sleeps. Among its risks is the thermal stress of the infant, the accumulation of carbon dioxide, age of the infant, esophageal reflux, type of feeding, sleep phase, gestation time and / or position of the infant when he sleeps. Epidemiological studies show that there is a higher probability of sudden death in premature infants. Likewise, the 25 neurophysiological parameters of the infant (respiratory rate, heart rate, oxygen saturation, temperature) have great variability.
    It has been postulated that the infant has not matured the control mechanisms in his awakening when apnea occurs and if these continue, the death of the infant is triggered.
    A solution to avoid the death of the infant would be to wake the infant every so often but would alter the cycles of rest of the infant.
    Object of the invention
    5 The problem solved by the invention is to find a method to prevent sudden infant death without altering the infant's sleep.
    In a first aspect, the solution found by the inventors is a method comprising the monitoring of the infant's breathing frequency, the detection of apnea and the application of a variable frequency vibration 10 when the apnea occurs.
    The vibration applied stimulates the infant, inducing an arousal, which normalizes breathing and does not wake the infant.
    In a particular way, if the applied vibration does not induce an arousal and the apnea continues, then the vibration frequency and time of application of the vibration is increased.
    In a particular way, if continuous apnea a vibration is applied continuously and warning signals are generated.
    The frequencies that produce an arousal without waking the infant are between 50 and 150Hz and are applied intermittently, such as 20 for example 4 or 5 seconds.
    In another aspect, the invention describes a suitable mattress to prevent sudden death of the infant. The mattress comprises in its interior means to generate a vibration, it comprises means to control the duration of the vibration and the vibration has a variable frequency and amplitude. The vibration generated induces an arousal that stimulates the infant without altering the infant's dream.
    In a preferred mode, the vibration frequencies are between 80 and 120 Hz.
    In a preferred mode, the vibration is generated by micromotors where the vibration frequency depends on the potential difference applied in the micromotors.
    In a particular way, the mattress comprises breathing sensors. This avoids placing ribbons with breathing sensors on the infant's chest.
    In a particular way, the mattress comprises means for regenerating sound or light warning signals. Alert signals allow parents to be notified in emergency situations, when apnea exceeds a threshold value,
    10 for example 20 seconds.
    Description of the figures
    Figure 1 shows the location of the micromotors.
    Figure 2 shows the algorithm to prevent sudden infant death
    Figures 3 A and 3B show the frequency and amplitude of the vibration as a function of the potential difference.
    Figure 4 shows the electrical scheme.
    Figure 5 shows the probability of inducing an arousal
    Detailed description of the invention
    The procedure described to prevent death comprises:
    20 -the monitoring of the infant's breathing rate,
    -the detection of apnea episodes and
    -the stimulation of the infant by the application of a vibration when an apnea occurs.
    The described method is performed by using a mattress that contains 25 vibrators inside, which produce a vibration, which induces an arousal that activate the infant's brain without waking the infant. The method is performed without
    medical supervision and is indicated to be performed at the infant's home.
    In a preferred mode, the mattress has integrated micromotors. The amplitude and frequency of the vibration are controlled by the application of a variable potential difference (Figure 3). The intensity and amplitude of the vibration is increased by increasing the potential difference in micromotors. Studies show that vibration frequencies between 50 Hz and 150 Hz produce an arousal that activates the infant's brain without causing the infant to wake up. In a preferred mode, the vibration frequency is between 80 and 120 Hz.
    The monitoring of the respiratory rate allows to detect apnea episodes and their duration. When the apnea period is greater than a threshold value, the system generates an intermittent vibration, if the apnea continues the generated vibration increases in intensity and amplitude.
    15 Finally, if after applying the maximum frequency of continuous vibration the apnea is applied a continuous vibration and the system can generate a light or audible alarm signal to notify the parents.
    The frequency of respiration of the infant is determined by methods known to the person skilled in the art: by bands attached to the chest of the mattress or by biosensors placed on the mattress. Also, the history of the breathing rate and apnea episodes are archived in a database.
    Studies (example 2) show that arousal induction depends on:
    25 - vibration level,
    - pregnancy time,
    - position of the infant,
    - age of the infant and / or
    - type of food.
    30 The results obtained, (figure 5) show that:
    - the probability of stimulating an arousal increases with the frequency of vibration,
    - the likelihood of stimulating an arousal in premature infants is greater than the term pregnancy infants,
    5 - the probability of stimulating an arousal is higher in infants than
    they sleep on their back that infants sleep on their side.
    - the probability of stimulating an arousal is greater in the REM phase.
    The results show that by applying a vibration between 50 and 10 150 Hz an arousal is induced without waking in more than 2/3 (69%) of the
    stimulations performed and, therefore, the risk of sudden infant death is reduced as the breathing of the infant is normalized.
    In cases where the arousal is not induced (1/3 of the stimulations) the system generates a continuous vibration that will normalize the frequency of 15 breaths.
    Based on the studies carried out, an appropriate algorithm has been developed to prevent sudden infant death, which is detailed in Figure 2. The algorithm describes the stimulation in risk and emergency situations. Risk situations occur when apnea is greater than 10 20 seconds and emergency situations occur when apnea is greater than 20 seconds.
    When the risk situation occurs, a temporary vibration is generated (45 seconds) The vibration frequency can vary between 50 and 150 Hz and preferably between 80-120 Hz.
    25 When the emergency situation occurs, a continuous vibration is generated with a frequency greater than 120 Hz and the system generates an alert signal.
    The described algorithm can be implemented in a computer program, which includes the history of the breathing rate, apnea episodes and the history of the vibrations applied together with other data of the infant: weight, type of feeding, gestation time or age of the mother.
    Optionally, the mattress may comprise other control or measurement devices, such as accelerometers, temperature sensors or position detectors.
    5 Example 1.
    For the tests detailed in example 2 I use the mattress detailed below. Six 6 micromotors (Precision Microdrives Model 312-17) were integrated inside the mattress (880 * 380 mm), as shown in Figure 1. The micromotors were encapsulated in a plastic housing.
    The vibration generated by micromotors was controlled by the difference in potential applied. The six engines were grouped into two groups, as detailed in the electrical scheme detailed in Figure 4.
    Figures 3A and 3B show the frequency and amplitude of the vibration as a function of the potential difference.
    Example 2. Tests performed
    To determine the level of vibration necessary to induce an arousal without waking the infant, the following test was performed on 36 infants.
    20 The age of infants and gestation time was:
     Months  Pregnancy at term Preterm birth
     (38-42 weeks) (32-38 weeks)
     2  3 3
     3 3 3
     4  3 3
     5  3 3
     6  3 3
     7-8  3 3
     TOTAL 36
    For each infant the following parameters were recorded: Sleep phases (N1, N2, N3 and REM), number of cycles, type of sleep according to parents (light, deep or normal), weight and height, position of the infant and type of feeding 5 (breast or bottle).
    During the sleep, the electrocardiogram, temperature, breathing rate, acceleration of the mattress were monitored due to the signals generated by the vibrators.
    The infants slept on the mattress detailed in Example 1. During the 10th sleep random vibrations were generated with a duration of 4 seconds by applying a potential of 1.7, 2.3 and 3 volts, which according to Table 3A corresponds at a frequency of 80, 100 and 120 Hz. The waiting time between two vibrations was 4 minutes.
    After each vibration stimulation a software recorded the phase of the dream, position and induction of the arousal.
    When the infant was not stimulated with a potential of 3 volts, a continuous vibration was generated.
    The results obtained in the stimulation of an arousal depending on the sleep phase were:
    Phase Result Sum Result
    Stimulation Stimulation
     Nothing Arousal Nothing Arousal
     N1  9 0 9 100% 0%
     N2  44 125 169 26% 74%
     N3  22 24 46 48% 52%
     REM  23 73 96 24% 76%
     TOTAL  98 222 320 31% 69%
    The results obtained in the stimulation of an arousal depending on the phase of the vibration level were:
     level  Outcome
     Stimulation
     Nothing Arousal
     1.7  43 68
     2.3  32 96
     3  23 58
     TOTAL  98 222
     Sum  Outcome
     Stimulation
     Nothing Arousal
     111  39% 61%
     128  25% 75%
     81  28% 72%
     320  31% 69%
    The results obtained in the stimulation of an arousal depending on the phase of the vibration level and the phase of the dream were:
     Level Result Sum Result
     Phase    Stimulation Stimulation
     Nothing Arousal Nothing Arousal
     N1  1.7 5 0 5 100% 0%
     N1  2.3 1 0 1 100% 0%
     N1  3 3 0 3 100% 0%
     N2  1.7 17 38 55 31% 69%
     N2  2.3 19 55 74 26% 74%
     N2  3 8 32 40 20% 80%
     N3  1.7 7 2 9 78% 22%
     N3  2.3 6 10 16 38% 63%
     N3  3 9 12 21 43% 57%
     REM  1.7 14 28 42 33% 67%
     REM  2.3 6 31 37 16% 84%
     REM  3 3 14 17 18% 82%
     TOTAL    98 222 320 31% 69%
    From the previous results, the algorithm described in Figure 2 was designed.
    权利要求:
    Claims (9)
    [1]
    5
    10
    fifteen
    twenty
    25
    Claims
    1. A method for the prevention of sudden infant death by inducing an arousal that activates the infant's brain without causing the infant to wake up comprising:
    to. the monitoring of the infant's breathing rate,
    b. the detection of apnea episodes,
    C. Infant stimulation by applying a vibration when apnea occurs,
    characterized in that the applied vibration is performed when the apnea is greater than 10 seconds.
    [2]
    2. The method according to claim 1 characterized in that the vibration stimulation is performed every 4-5 seconds.
    [3]
    3. The method according to claims 1-2 characterized in that the vibration has a frequency between 50 and 150 Hz.
    [4]
    4. The method according to claims 1-3 characterized in that when the apnea is greater than 20 seconds a continuous vibration with a frequency greater than 120 Hz is applied.
    [5]
    5. The method according to claim 4 characterized in that an alert signal is generated.
    [6]
    6. Mattress suitable for the prevention of sudden death of the infant comprising:
    to. inside means to generate a vibration,
    b. means to control the duration of vibration,
    characterized in that the vibration has a variable frequency and amplitude 5 and is generated by micromotors depending on the potential
    applied.
    [7]
    7. Mattress according to claims 6 characterized in that the frequency is between 50-150 Hz.
    10. Mattress according to claims 6-7 characterized in that it comprises
    a breath rate sensor.
    [9]
    9. Mattress according to claims 6-8, characterized in that it contains means for generating an alert signal.
    fifteen
    [10]
    10. Use of the mattresses according to claims 6-8 for the induction of an arousal that activates the infant's brain without waking the infant.
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    同族专利:
    公开号 | 公开日
    ES2630368B1|2018-04-27|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5555891A|1994-05-20|1996-09-17|Hartford Hospital|Vibrotactile stimulator system for detecting and interrupting apnea in infants|
    WO1996028093A1|1995-03-09|1996-09-19|St. Elizabeth's Medical Center Of Boston, Inc.|Apparatus and process for reducing the frequency and duration of apneic events|
    CA2310238A1|2000-06-14|2001-12-14|Ian G. Auchinleck|Vibrating stimulation system for interrupting apnea in infants|
    WO2011071938A2|2009-12-07|2011-06-16|Mark Shinnick|Method and device preserving of infant sleep and avoidance of infant adaptation|
    法律状态:
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